THC Tolerance - How to Avoid It and Tolerance Breaks

Sometimes a dose that once worked well gives a weaker and weaker effect over time. This does not mean the therapy has stopped making sense - it is often about THC tolerance. It is worth understanding this mechanism so you do not raise the dose unnecessarily.

With regular THC intake the CB1 receptors it acts on become less sensitive and there are temporarily fewer of them on the cell surface. The body gets used to it, so the same effect requires a larger dose. This is a natural and reversible phenomenon.

Good news: tolerance is not addiction. We cover the difference in does medical cannabis cause addiction.

A few rules help keep therapy effective at a reasonable dose:

Sometimes, instead of raising the dose, it is better to change the strain profile or the form - that is the doctor's assessment.

A tolerance break is a few days without THC (or with a clearly reduced dose) that let the CB1 receptors regain sensitivity. After such a break a smaller dose works effectively again.

You do not introduce a break on your own with serious indications - always agree with your doctor whether and how long it is safe in your case.

Therapy run under a doctor's supervision is the best protection against an unnecessary dose increase. At the follow-up we assess the effects and, if needed, adjust the profile or schedule.

If you are starting out, see the guide dosing medical cannabis. You book visits at 731 000 645.